α2-Macroglobulin from bovine plasma
10602442001 25 inhibitor units
Product Description
Specificity: Universal protease inhibitor that blocks most endoproteinases. Not affected are endoproteinases that are highly specific for one or a limited number of sequences such as tissue kallikrein, urokinase, factor XIIa, and endoproteinase Lys-C.
Specific activity: approx. 1 inhibitor U/mg protein (tested with trypsin at 25°C and Chromozym TRY as substrate).
Solubility/Stability: Soluble in water. Stable for at least 1 week at room temperature or 3 weeks at +2 to +8°C. Can also be frozen in aliquots at -15 to -25°C, where it remains stable for at least 6 months. Sensitive to acidic pH, denatured below pH 4.0. Ammonia methylamine and hydroxylamine (above pH 7.0) cause irreversible conversion to the inactive form.
Contents
Lyophilizate, contains 6% BSA
Notes
Do not use α2-macroglobulin in the presence of DTT since it causes a (reversible) dissociation into inactive subunits. α2-macroglobulin acts by physically entrapping endoproteinases, usually in a 1:1 ratio