Angiotensin II, Human
Plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60c-src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.
Peptide Sequence  H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Form  White to off-white solid
Primary Target  adenylate cyclase activity
Molar mass  1046.2
Hygrocopic  是的
Purity  ≥98% by HPLC
Sold on the basis of peptide content  是的
Solubility  H2O or 5% Acetic Acid
Chemical formula  C50H71N13O12
RTECS  BW2165000
CAS number  4474-91-3
Merck USA index 14 651
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling