Anti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. At higher concentrations, DNA polymerase is inhibited. Also acts as a competitive inhibitor of serine proteases. Inhibits cell growth and colony formation in synchronized HeLa cells. Induces apoptosis in many cell lines. However, actinomycin D has also been shown to suppress etoposide-induced apoptosis in PC12 cells. Note: 1 set = 20 x 200 µg. Stability: heat resistant and stable between pH 2 and 11. Decomposed by strong acids and bases.
Form  Red crystalline solid 
Primary Target  serine proteases 
Secondary target  cell growth and colony formation in synchronized HeLa cells 
Protect from Light  是的 
Hygrocopic  是的 
Purity  ≥98% by HPLC 
Chemical formula  C62H86N12O16 
RTECS  AU1575000 
CAS number  50-76-0 
Merck USA index  14, 2800 
Storage  +2°C to +8°C 
Ship  Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic 
凋亡作為一種正常的細(xì)胞生物學(xué)行為，其研究需要一系列嚴(yán)格的實(shí)驗(yàn)程序，這可以通過(guò)多種誘導(dǎo)劑刺激細(xì)胞膜受體或激活線(xiàn)粒體調(diào)亡途徑來(lái)誘導(dǎo)細(xì)胞的凋亡。