Apoptosis Inhibitor II, NS3694 
A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
產(chǎn)品信息
Form  White solid
Primary Target  completely blocks TNF-α-induced death in MCF-casp3 cells
Primary Target IC50  50 µM
Molar mass  358.7
Protect from Light  是的
Cell permeable  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C15H10ClF3N2O3
CAS number  426834-38-0
商店和運輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling