MG-132
Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available.
產(chǎn)品信息
Peptide Sequence  Z-Leu-Leu-Leu-CHO
Form  White solid
Primary Target  proteasome
Primary Target Ki  4 nM
Secondary target  NF-κB (IC50 = 3 µM)
Molar mass  475.6
Cell permeable  是的
Reversible  是的
Purity  ≥98% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C26H41N3O5
CAS number  133407-82-6
商店和運(yùn)輸信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling