(±)-Propranolol, Hydrochloride
(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
A highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.
產(chǎn)品信息
Form  White solid
Molar mass  295.8
Purity  ≥98% by titration
Solubility  MeOH or H2O
Chemical formula  C16H21NO2 · HCl
RTECS  UB7526000
CAS number  3506-09-0
Merck USA index 14, 7840
商店和運(yùn)輸信息
Storage  -20°C
Ship  Ambient Temperature Only
Harmful