PAR-2 Agonist I
Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide
The native PAR-2-specific agonist, SLIGRL-NH2, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2-/- mice. Reactive towards human, rat, and murine PAR-2.
產(chǎn)品信息
Peptide Sequence  2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH2
Form  White lyophilized solid
Formulation  Supplied as a trifluoroacetate salt.
Molar mass  663.8
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C31H53N9O7
商店和運輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling