PTP1B Inhibitor
3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
A cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749).
產(chǎn)品信息
Form  White solid
Primary Target  PTP1B403
Primary Target IC50  4 µM
Secondary target  IC50 = 8 µM for PTP1B298
Molar mass  741.5
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥95% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C26H19Br2N3O7S3
CAS number  765317-72-4
商店和運(yùn)輸信息
Storage  -20°C
Ship  Blue Ice Only
Standard Handling