Rb/Raf-1 Disruptor 251
S-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251
A cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction (IC50 = 77 nM in cell-free binding assays), while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/prohibitin, Rb/cyclin E, Rb/HDAC1, Raf-1/MEK1, or Raf-1/MEK2 interaction. Suppresses cellular E2F transcription activity and reduces serum-induced Rb phosphorylation. Shown to display Rb-dependent antitumor activity both in cultures in vitro and in mice in vivo.
產(chǎn)品信息
Form  White solid
Molar mass  271.6
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C8H9Cl3N2S
CAS number  72214-67-6
商店和運(yùn)輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Irritant