Y-27632
ROCK Inhibitor, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. Pretreatment with Y-27632 reduces the risk of lung injury in rat models of sepsis. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and a 10 mM solution in DMSO (Cat. No. 688002) are also available.
產(chǎn)品信息
Form  White solid
Primary Target  p160ROCK
Primary Target Ki  140 nM
Molar mass  338.3
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Cell permeable  是的
ATP Competitive  是的
Purity  ≥95% by HPLC
Solubility  H2O
Chemical formula  C14H21N3O · 2HCl · H2O
CAS number  146986-50-7
Declaration  Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
商店和運(yùn)輸信息
Storage  -20°C
Ship  Ambient Temperature Only
Harmful