688001  InSolution™ Y-27632
Rho Kinase Inhibitor VI
A highly potent, cell-permeable, selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 mM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips).
產(chǎn)品信息 
Form  Liquid 
Formulation  A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H2O. 
Primary Target  p160ROCK 
Primary Target Ki  140 nM 
Protect from Light  是的 
Packaged under inert gas  是的 
Purity  ≥95% by HPLC 
Chemical formula  C14H21N3O · 2HCl · H2O 
Declaration  Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation. 
商店和運輸信息 
Storage  -20°C 
Ship  Blue Ice Only
Harmful 
安全標示 
S Phrase  S: 36
Wear suitable protective clothing. 
R Phrase  R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed