Recombinant Human TPO|Human TPO|現(xiàn)貨進(jìn)口
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Source: E.coli
Description:
TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Cross Reactivity: Monkey, Mouse, Human. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Manufactured using all non-animal reagents.