英文名: Decitabine; 5-Aza-2'-deoxycytidine
中文名: 地西他濱,5-氮雜-2'-脫氧胞嘧啶核
用途:地西他濱作為特異的 DNA甲基化轉移酶抑制劑 ,可逆轉 DNA的甲基化過程，誘導腫瘤細胞向正常細胞分化或誘導腫瘤細胞凋亡。在腫瘤細胞內，地西他濱被脫氧胞苷激酶磷酸化，以磷酸鹽的形式與 DNA摻合。高濃度的地西他濱摻合可抑制 DNA合成誘導細胞死亡，發(fā)揮其細胞毒作用;低濃度的地西他濱摻合可替代腫瘤細胞內的胞嘧啶與 DNA甲基化轉移酶共價結合，使 DNA甲基化轉移酶失活但不會導致細胞死亡。
地西他濱的適應證為骨髓增生異常綜合征，另有研究，其對鐮狀細胞性貧血、髓性細胞白血病以及一些實體瘤也有療效。
外觀：白色或類白色結晶粉末
SIGMA相關產品資料如下：
Sigma  A3656  5-Aza-2′-deoxycytidine ≥97%
Synonym: 2′-Deoxy-5-azacytidine, Decitabine, 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
CAS Number: 2353-33-5
Linear Formula: C8H12N4O4
Molecular Weight: 228.21
Description
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Related Keywords 2′-Deoxy-5-azacytidine, Decitabine, Azadc, Aza dC, Dezocitidine, 4-Amino-1-(2-deoxy-beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5-Aza-2-deoxycytidine, epigenetic, ADC, 5-aza-CdR, 5-aza-dC,decitabine, demethylation, DNA, hypomethylating, chromatin, p53, p21, cip1, butryate, methylation
General description Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling “opening” chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the 點擊查看詳細