ORN06/LyoVec™
ORN 06 contains 6 repeats of the UUGU sequence motif, identified as the minimal motif responsible for ssRNA40 immunoactivity. ORN06 is complexed with the cationic lipid LyoVec™, to protect it from degradation and facilitate it uptake. ORN 06/LyoVec™ has been tested using HEK-Blue™ TLR7 and HEK-Blue™ TLR8 Cells to confirm its specificity.
Specificity: human TLR8/mouse TLR7 agonist
Working Concentration: 0.25 - 5 μg/ml
Sequence: ORN 06 5’-UUGUUGUUGUUGUUGUUGUU-3’ (20 mer)
Endotoxin level:  EndoFit™ (<0.001 EU/µg)
Solubility: 0.05 mg/ml in water