Poly(dA:dT)
Synthetic analog of B-DNA
Poly(dA:dT) is a poly(deoxyadenylic-deoxythymidylic) acid sodium salt. It is a repetitive synthetic double-stranded DNA sequence of poly(dA-dT)•poly(dT-dA) and a synthetic analog of B-DNA. Poly(dA:dT) is recognized by several sensors, including DAI, LRRFIP1 and AIM2. Poly(dA:dT) is also indirectly detected by RIG-I. The activity of poly(dA:dT) is tested using the reporter cell line B16-Blue™ IFNα/β.
Poly(dA:dT) is also available complexed with the cationic lipid transfection reagent LyoVec™ to facilitate its uptake.
Activity: RIG-I & CDS agonist, AIM2 inflammasome inducer
Formulation: naked
CAS number: 86828-69-5
Solubility: 2 mg/ml in physiological water
Endotoxin level: EndoFit™ (<0.001 EU/µg)