Pepinh-MYD
MyD88 Inhibitory Peptide
Pepinh-MYD is a 26 aa peptide that blocks MyD88 signaling by inhibiting its homodimerization through binding. Pepinh-MYD contains a sequence from the MyD88 TIR homodimerization domain (RDVLPGT) [1] preceeded by a protein transduction sequence (RQIKIWFQNRRMKWKK) derived from antennapedia which enables the peptide to translocate through the cell membrane [2]. Pepinh-MYD is provided with Pepinh-Control, a control peptide [3].
Working concentration: 5-50 μM
Endotoxin level: <0.125 EU/mg
Purity: >95% (HPLC)
Species reactivity: Human, mouse
Sequences:
• Pepinh-MYD:    RQIKIWFQNRRMKWKK-RDVLPGTCVNS-NH2 (MyD88 homodimerization sequence is underlined)
• Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2
Molecular weights:
• Pepinh-MYD: 3430
• Pepinh-Control: 3812