雷帕霉素,西羅莫司英文名: Sirolimus;Rapamycin;AY 22989;FRAP;FAFTRapamycin也稱(chēng)AY 22989或sirolimus,可與FKBP12形成復(fù)合物,隨后結(jié)合并抑制FRAP/mTOR。mTOR是哺乳動(dòng)物中rapamycin的作用靶點(diǎn),也被稱(chēng)為FRAP或FAFT,是一個(gè)Ser/Thr蛋白激酶,可以激活p70 S6 kinase。Rapamycin對(duì)于p70 S6 kinase的抑制作用的IC50為0.05nM。Rapamycin通過(guò)抑制FRAP/mTOR可以抑制p70 S6 kinase的磷酸化和激活,抑制4E-BP1/PHAS1的磷酸化并促進(jìn)其對(duì)eIF4E的結(jié)合和抑制。LC Laboratories相關(guān)資料如下:R-5000 Rapamycin, >99%M.W. 914.17 C51H79NO13 [53123-88-9]RTECS: VE6250000 M.I. 12: 8288 M.I. 14: 8114Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol (up to about 50 mg/mL for either solvent).