PON1 Activator, ZNPA
(Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
A cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (> 3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
產(chǎn)品信息
Form  Pale yellow solid
Molar mass  295.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C15H9N3O4
商店和運(yùn)輸信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling