產品介紹:
       二氫睪酮（dihydrotestosteroneC19H30O2）。亦稱17β－羥基-5α-雄[甾]烷-3-酮、5α－二氫睪酮、5α－DHT、或雄烷酮（stanorone）。是睪酮的雙鍵在5α處被還原的甾醇。對附屬腺（前列腺、精囊腺等），起著所謂的真的雄性激素的作用。在附屬性腺的細胞中存在著形成該甾醇的5α-氫化酶。該甾醇和受體蛋白質在細胞內結合成的復合體進入附屬腺的細胞核中，促進新的蛋白質合成。顯示出比睪酮稍強的雄性激素作用。5β-體雖在肝臟、雞冠等中以睪酮形態(tài)存在，但是沒有雄性激素的作用。5α－二氫睪酮由于3α-羥基甾醇脫氫酶的作用而代謝成為5α-雄烷-3α－17β-二醇排出體外。
Sigma相關產品資料:
Sigma A8380  5α-Androstan-17β-ol-3-one   ≥97.5%
Synonym:17β-Hydroxy-5α-androstan-3-one, 4,5α-Dihydrotestosterone, Androstanolone, Stanolone
CAS Number:521-18-6
Linear Formula: C19H30O2
Molecular Weight:290.44
Beilstein Registry Number:2056371
EC Number:208-307-3
MDL number:MFCD00003667
PubChem Substance ID:24891337
Description
Biochem/physiol Actions Anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.
性質
assay ≥97.5%
drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
Gene Information human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
  rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
  mouse ... Esr1(13982)