LY 294002|LY294002|LY-294002

產(chǎn)品編號(hào)：440202-5MG 

產(chǎn)品名稱：LY 294002|LY294002|LY-294002  

供應(yīng)商：Merck

規(guī)格：5MG

目錄價(jià)：2,092.00

庫(kù)存狀態(tài)：現(xiàn)貨

CAS編號(hào)：154447-36-6

相關(guān)信息：

440202  LY 294002 

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available. 

Product information  

Form  Off-white solid  

Primary Target  specific phosphatidylinositol 3-kinase inhibitor  

Primary Target IC50  1.4 µM  

Molar mass  307.4  

Protect from Light  Yes  

Cell permeable  Yes  

Purity  ≥98% by HPLC  

Solubility  DMSO or EtOH  

Chemical formula  C19H17NO3  

CAS number  154447-36-6  

Store and ship information   

Storage  -20°C  

Ship  Ambient Temperature Only 

Standard Handling