產(chǎn)品編號(hào)：15386-500 

產(chǎn)品名稱：Ikarugamycin  

供應(yīng)商：Cayman

規(guī)格： 500 μg

目錄價(jià)：2226

Ikarugamycin

Cayman Chemical Item Number 15386

(CAS 36531-78-9)

Description

Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity.1 It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC50 = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases.2 It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 μM.3 Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.4

Formal Name(2R,3R,7Z,14S,19E)-3-ethyl-2,3,3aS,5aR,5bS,6,10,11,12,13,14,15,20aS,21,21aR,21bR-hexadecahydro-22-hydroxy-2-methyl-14,17-metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione

CAS Number36531-78-9

Molecular FormulaC29H38N2O4

Formula Weight478.6

FormulationA white solid

Purity≥99%

Stability2 years

Storage-20°C

Shipping Room temperature in continental US; may vary elsewhere

SMILESCopy O=C(C1=C(O)[C@H](CCCN2)NC1=O)/C=C/[C@@H]3C[C@@]4([H])[C@@](C=C[C@]5([H])[C@]4([H])C[C@@H](C)[C@H]5CC)([H])[C@H]3C/C=C\C2=O

InCHI CodeCopy 1S/C29H38N2O4/c1-3-18-16(2)14-22-20(18)10-11-21-19-6-4-8-26(33)30-13-5-7-24-28(34)27(29(35)31-24)25(32)12-9-17(19)15-23(21)22/h4,8-12,16-24,34H,3,5-7,13-15H2,1-2H3,(H,30,33)(H,31,35)/b8-4-,12-9+/t16-,17-,18-,19+,20+,21-,22+,23+,24+/m1/s1

InCHI KeyCopy WSUGGLXIPUHOSG-QOMLVTEJSA-N