GDNF, human recombinant
A promotor of dopamine uptake and survival of midbrain neurons
Product Overview
Alternate Names / Synonyms: human GDNF, GDNF, h-GDNF, rh-GDNF, recombinant human GDNF, recombinant GDNF
Gene Symbol: GDNF
Accession #: P39905
Gene ID: 2668
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from 10 mM Sodium Citrate + 150 mM NaCl, pH 4.0.
Molecular Weight: 30.1 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as determined by the dose-dependent dopamine uptake by rat ventral mesencephalic cultures was found to be in the range of 4-8 ng/ml.
Reconstitution Instructions: Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: Human GDNF (Glial-Derived Neurotrophic Factor) is a 30.1 kDa protein that specifically promotes dopamine uptake and survival of midbrain neurons. GDNF is a disslphide-linked homodimer, formed by two identical 134 amino acids subunits.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.