A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
Form  White solid 
Primary Target  DNA polymerase α, DNA polymerase δ 
Cell permeable  是的 
Purity  ≥98% by TLC 
Chemical formula  C20H34O4 
RTECS  PB9185000 
CAS number  38966-21-1 
Merck USA index  14, 727 
Aphidicolin
凋亡作為一種正常的細(xì)胞生物學(xué)行為，其研究需要一系列嚴(yán)格的實(shí)驗(yàn)程序，這可以通過(guò)多種誘導(dǎo)劑刺激細(xì)胞膜受體或激活線粒體調(diào)亡途徑來(lái)誘導(dǎo)細(xì)胞的凋亡。