PD 158780
4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH 3T3 cells. A 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513036) in DMSO is also available.
產(chǎn)品信息
Form  Yellow solid
Primary Target  EGFR
Primary Target IC50  8 pM
Molar mass  330.2
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C14H12BrN5
CAS number  171179-06-9
商店和運(yùn)輸信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling