PD 168393
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
產(chǎn)品信息
Form  Yellow solid
Primary Target  EGFR
Primary Target IC50  700 pM
Molar mass  369.2
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C17H13BrN4O
CAS number  194423-15-9
商店和運(yùn)輸信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling