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PKC BETA II INHIBITOR/EGFR *CGP53353*

產(chǎn)品編號: 539652-2MG     查看說明書
產(chǎn)品名稱: PKC BETA II INHIBITOR/EGFR *CGP53353*  .0   訂購此產(chǎn)品 
供應(yīng)商: Merck
規(guī)格: ***
目錄價: 2200
庫存狀態(tài): 3周到貨
CAS編號: 145915-60-2
應(yīng)用范圍: 生化實驗
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相關(guān)信息:

PKCβII/EGFR Inhibitor
CGP 53 353, CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide
A cell-permeable symmetrical phthalimide compound that acts as a potent, reversible, and ATP-competitive inhibitor of EGFR and PKC isozymes α, βI, and βII (IC50 = 0.7 µM, 1.9 µM, 3.8 µM, and 0.41 µM, respectively). Only weakly inhibits the activity of a panel of 16 other kinases, including novel and atypical PKC isozymes. Reported to inhibit insulin-stimulated cellular 2-deoxyglucose uptake, osteoclast differentiation, ERK activation, and TLS/FUS DNA-binding activity in vitro. Also reported to exhibit antitumor activity in mice in vivo.
產(chǎn)品信息
Form  Orange solid
Primary Target  EGFR
Primary Target IC50  0.7 µM
Secondary target  PKC isozymes α, βI, and βII (IC50 =1.9 µM, 3.8 µM, and 0.41 µM, respectively)
Molar mass  365.3
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
ATP Competitive  是的
Purity  ≥98% by HPLC
Solubility  DMSO
Chemical formula  C20H13F2N3O2
CAS number  145915-60-2
商店和運(yùn)輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

保存條件: 2°C - 8°C
說明書地址: 點擊查看詳細(xì)
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