PKCβII/EGFR Inhibitor
CGP 53 353, CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide
A cell-permeable symmetrical phthalimide compound that acts as a potent, reversible, and ATP-competitive inhibitor of EGFR and PKC isozymes α, βI, and βII (IC50 = 0.7 µM, 1.9 µM, 3.8 µM, and 0.41 µM, respectively). Only weakly inhibits the activity of a panel of 16 other kinases, including novel and atypical PKC isozymes. Reported to inhibit insulin-stimulated cellular 2-deoxyglucose uptake, osteoclast differentiation, ERK activation, and TLS/FUS DNA-binding activity in vitro. Also reported to exhibit antitumor activity in mice in vivo.
產(chǎn)品信息
Form Orange solid
Primary Target EGFR
Primary Target IC50 0.7 µM
Secondary target PKC isozymes α, βI, and βII (IC50 =1.9 µM, 3.8 µM, and 0.41 µM, respectively)
Molar mass 365.3
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C20H13F2N3O2
CAS number 145915-60-2
商店和運(yùn)輸信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |