Rottlerin
Mallotoxin
A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
產(chǎn)品信息
Form  Orange solid
Primary Target  PKCδ
Primary Target IC50  3-6 µM
Secondary target  PKCα, PKCβ, and PKCγ (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM)
Molar mass  516.5
Purity  ≥98% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C30H28O8
RTECS  AM6913800
CAS number  82-08-6
Merck USA index 14, 8272
商店和運輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling