Ro-31-7549, Monohydrate
2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate, Bisindolylmaleimide VIII, Acetate
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
產品信息
Form  Red to reddish-orange solid
Primary Target  rat brain PKC
Primary Target IC50  158 nM
Secondary target  IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε. Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
Molar mass  476.5
Protect from Light  是的
Purity  ≥93% by HPLC
Solubility  DMSO
Chemical formula  C24H22N4O2 · C2H4O2 • H2O
CAS number  125313-65-7
商店和運輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling