Ro-31-8425
2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε).
產(chǎn)品信息
Form  Reddish-orange solid
Primary Target  PKC
Primary Target IC50  15 nM
Secondary target  PKCα (IC50 = 8 nM), PKCβI (IC50 = 8 nM), PKCβII (IC50 = 14 nM)
Molar mass  461.0
Protect from Light  是的
Purity  ≥94% by HPLC
Solubility  DMSO
Chemical formula  C26H24N4O2 · HCl
CAS number  131848-97-0
商店和運(yùn)輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Irritant