InSolution™ Ro-31-8220
3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
Form  Clear orange-brown liquid
Formulation  A 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H2O.
Primary Target  PKC
Primary Target IC50  10 nM
Secondary target  CaM kinase II (IC50 = 17 µM) and protein kinase A (IC50 = 900 nM). Potently inhibits GSK-3 in primary adipocytes (IC50 = 6.8 nM) and in GSK-3b immunoprecipitates (IC50 = 2.8 nM). An inhibitor of MAP kinase phosphatase-1 expression and an activator of JNK1. Inhibits the phosphorylation of Raf-1 and induces apoptosis, independent of its effects on PKC, in HL-60 cells.
Molar mass  553.7
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Chemical formula  C25H23N5O2S • CH3SO3H
商店和運(yùn)輸信息
Storage  -20°C
Ship  Blue Ice Only
Standard Handling