Ro-32-0432
2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide XI, HCl, 3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over PKCε (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo.
產(chǎn)品信息
Form  Red solid
Primary Target  PKCα
Primary Target IC50  9 nM
Secondary target  PKCβI (IC50 = 28 nM), PKCδ (IC50 = 108 nM)
Molar mass  489.0
Protect from Light  是的
Cell permeable  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C28H28N4O2 · HCl
CAS number  145333-02-4
商店和運(yùn)輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling