Wnt Antagonist II, IWP-2
Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
產(chǎn)品信息
Form  Off-white solid
Molar mass  466.6
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C22H18N4O2S
CAS number  686770-61-6
商店和運(yùn)輸信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Harmful