Wnt Antagonist III, Box5
Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
產(chǎn)品信息
Peptide Sequence  t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO2H
Form  White lyophilized solid
Molar mass  766.9
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥90% by HPLC
Solubility  DMSO or H2O
Chemical formula  C30H50N6O13S2
商店和運(yùn)輸信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling