Triptolide
NF-κB inhibitor
Triptolide, a diterpenoid isolated from Tripterygium wilfordii hook F, has been used for centuries in traditional Chinese medicine to treat immune-related disorders. In addition to its anti-inflammatory and immunosuppressive activities, triptolide possesses potent antitumor properties. In a broad range of human tumor cells, Triptolide suppresses cell proliferation and induces apoptosis through caspase activation [1]. At a molecular level, Triptolide inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) [2], and by inhibiting the ATPase activity of XPB [3], a subunit of the general transcription factor TFIIH.  Triptolide interferes with a number of transcription factors including p53 [4], NF-κB [5], nuclear factor of activated T-cells (NFAT) [5] and heat shock factor protein 1 (HSF-1) [6].
Working concentration: 10 - 100 nM
CAS number: 38748-32-2
Molecular weight: 360.4
Solubility: DMSO, ethanol (10 mg/ml)