Poly(I:C) LMW Polyinosinic-polycytidylic acid (poly(I:C)) is a synthetic analog of double-stranded RNA (dsRNA), a molecular pattern associated with viral infection. Poly(I:C) is recognized by TLR3 inducing the activation of NF-kB and the production of cytokines. Poly(I:C) is composed of a strand of poly(I) annealed to a strand of poly(C). The size of the strands varies. InvivoGen is the only company to provide poly(I:C) with two different sizes: • Poly(I:C) (HMW) with a high molecular weight has an average size of 1.5-8 kb. • Poly(I:C) (LMW) with a low molecular weight has an average size of 0.2-1 kb More Information (PDF) CAS number: 31852-29-6 Working concentration: 30 ng - 10 μg/ml Endotoxin level: <0.05 EU/μg Solubility: 20 mg/ml in physiological water (NaCl 0.9%)