中文名稱: 花生四烯酸,花生油烯酸 ，全順式-5，8，11，14-二十碳四烯酸AA
英文名稱:Arachidonic acid ,ARA cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid
Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid
5,8,11,14-Eicosatetraenoic Acid
5,8,11,14-Icosatetraenoic Acid
說明:花生四烯酸是（全順式-5，8，11，14-二十碳四烯酸）化學(xué)式如下：CH3(CH2)4(CH=CH-CH2)4(CH2)2COOH 屬于不飽和脂肪酸，其中含有四個碳-碳雙鍵，一個碳-氧雙鍵。
藥理作用:具有興奮子宮的作用[3～5]。能延長大鼠妊娠[6]。對胃酸的分泌有抑制活性[7]。
用 途: 安定, 抗消化性潰瘍及胃腸功能障礙, 作用于子宮 ；ㄉ南┧崾侨梭w大腦和視神經(jīng)發(fā)育的重要物質(zhì)，對提高智力和增強視敏度具有重要作用。 花生四烯酸具有酯化膽固醇、增加血管彈性、降低血液粘度，調(diào)節(jié)血細(xì)胞功能等一系列生理活性。 花生四烯酸對預(yù)防心血管疾病、糖尿病和腫瘤等具有重要功效。
Simga相關(guān)產(chǎn)品資料
Sigma 10931 Arachidonic acid
>95.0% (GC)
Synonym: cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid, Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid
CAS Number: 506-32-1
Linear Formula: CH3(CH2)4(CH=CHCH2)4CH2CH2CO2H
Molecular Weight: 304.47
Beilstein Registry Number: 1713889
EC Number: 208-033-4
MDL number: MFCD00004417
PubChem Substance ID: 24846907
Description
Biochem/physiol Actions Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the α subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
Quality Sigma-Aldrich will cha