MERCK相關(guān)產(chǎn)品資料：
440202  LY 294002 ( LY 294002 )
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
產(chǎn)品信息
Form  Off-white solid
Primary Target  specific phosphatidylinositol 3-kinase inhibitor
Primary Target IC50  1.4 µM
Molar mass  307.4
Protect from Light  Yes
Cell permeable  Yes
Purity  ≥98% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C19H17NO3
CAS number  154447-36-6
Store and ship information
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling