513000  PD 98059 ( PD 98059 )
2′-Amino-3′-methoxyflavone
Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 µM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.
產(chǎn)品信息
Form  Pale yellow solid
Molar mass  267.3
Protect from Light  Yes
Purity  ≥98% by HPLC
Solubility  DMSO or MeOH
Chemical formula  C16H13NO3
CAS number  167869-21-8
Store and ship information
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling