420119  JNK Inhibitor II ( JNK Inhibitor II )
Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
產(chǎn)品信息
Form  Yellowish orange solid
Primary Target  JNK 1, JNK 2, JNK 3
Primary Target IC50  40 nM, 40 nM, 90 nM
Molar mass  220.2
Protect from Light  Yes
Packaged under inert gas  Yes
Cell permeable  Yes
Reversible  Yes
ATP Competitive  Yes
Purity  ≥98% by HPLC
Solubility  DMSO
Chemical formula  C14H8N2O
RTECS  CB4585000
CAS number  129-56-6
Store and ship information
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