681675  Wortmannin ( Wortmannin )
KY 12420
A cell-permeable, fungal metabolite that acts as a potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase in purified preparations and cytosolic fractions (IC50 = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P3 formation (IC50 = 5 nM). Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (200 - 300 nM). Also inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM) and PI 4-kinase at concentrations higher than that required for inhibition of PI 3-kinase. Also blocks phospholipase D. A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681676) in DMSO is also available.
產(chǎn)品信息 
Form White to off-white solid 
Primary Target  phosphatidylinositol-3-kinase 
Primary Target IC50 5 nM
Secondary target mlck (IC,sub>50 = 200 nM)
Molar mass 428.4
Protect from Light Yes
Packaged under inert gas Yes
Cell permeable Yes 
Purity  ≥95% by HPLC 
Solubility DMSO or MeOH
Chemical formula C23H24O8
RTECS CB9641000 
CAS number 19545-26-7 
Merck USA index  14, 10053
Store and ship information
Hazardous Materials Attention:</b> Due to the nature of the Hazardous Materials in this shipment, additional shipping charges <i>may</i> be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage :-20°C 
Ship: Ambient Temperature Only Highly Toxic