產(chǎn)品編號(hào)：70440-500    

產(chǎn)品名稱：Filipin III  

供應(yīng)商：Cayman

規(guī)格：500 ug

目錄價(jià)：1246

Filipin III

Cayman Chemical Item Number 70440

(CAS 480-49-9)

Description

Cholesterol is both an important structural component of cell membranes and an early intermediate in hormone and bile acid biosynthesis. The localization and measurement of cholesterol in cells is therefore of great interest. Filipin is the collective name given to four isomeric polyene macrolides isolated from cultures of S. filipinensis; Filipin III is the predominant isomer and the one used in most studies. Filipin binds to cholesterol in membranes, forming ultrastructural aggregates and complexes which can be visualized by freeze-fracture electron microscopy.1,2 The binding of cholesterol also decreases the intrinsic fluorescence of Filipin, and this property has also been used to detect cholesterol in membrane fractions.3

Formal Name4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,21E,23E,25E-pentaen-2-one

CAS Number480-49-9

Molecular FormulaC35H58O11

Formula Weight654.8

FormulationA crystalline solid

Purity≥85%

λmax323, 339, 357 nm

Stability1 year

Storage-20°C

Shipping Room temperature in continental US; may vary elsewhere

SMILESCopy O[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O

InCHI CodeCopy 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-

InCHI KeyCopy IMQSIXYSKPIGPD-YQRUMEKGSA-N